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KMID : 1035620220100020073
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Allergy Asthma & Respiratory Disease
2022 Volume.10 No. 2 p.73 ~ p.79
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Risk factors and protective factors in pediatric patients with allergic rhinitis
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Chun Yoon-Hong
Kim Min-Ji
Kim Hyo-Bin
Rha Yeong-Ho
Park Yang
Park Yong-Mean
Sung Myong-Soon
Shin Youn-Ho
Yum Hye-Yung
Lee Kyung-Suk
Lee Yong-Ju
Jee Hye-Mi
Choi Bong-Seok
Choi Sun-Hee
Kim Hyun-Hee
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Abstract
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Among allergic diseases of the Korean pediatric population, allergic rhinitis shows the most rapidly increasing prevalence. Its economic burden is substantial in many Asian countries including South Korea. This investigation of its risk factors aims to reduce the socioeconomic burden by blocking exposure of susceptible individuals to identified causes. However, the risk factors of allergic rhinitis varied considerably depending on the seasons, geographical locations, and populations involved. This review article primarily deals with studies on the risk factors for allergic rhinitis in Korean children that were published during the last 10 years and additionally investigates associated large scale international studies. Our investigation identified several single-nucleotide polymorphisms, inhalant allergens, pollution, tobacco smoke, chemicals, and family affluence as risk factors for allergic rhinitis. In contrast, breastfeeding, older sibling, and microbial diversity were protective factors against allergic rhinitis. This suggests that various genetic and environmental factors might affect the manifestation and presentation of allergic rhinitis complexly. These findings are beneficial as they can provide insights into modifiable risk factors that may hinder the development of allergic rhinitis.
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KEYWORD
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Allergic rhinitis, Risk factors, Pediatric patients, Protective factors
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